Reduced Endothelial Vascular Relaxation in Growth-Restricted Offspring of Pregnant Rats With Reduced Uterine Perfusion
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چکیده
منابع مشابه
Reduced endothelial vascular relaxation in growth-restricted offspring of pregnant rats with reduced uterine perfusion.
Low birth weight as the result of placental insufficiency increases the risk of hypertension in young adults; however, the vascular mechanisms involved are unclear. We tested the hypothesis that intrauterine fetal growth restriction caused by placental insufficiency results in low-birth-weight offspring with impaired endothelium-dependent vascular relaxation, enhanced vasoconstriction, and hype...
متن کاملReduced Endothelial Vascular Relaxation in Growth-Restricted Offspring of Pregnant Rats
Low birth weight as the result of placental insufficiency increases the risk of hypertension in young adults; however, the vascular mechanisms involved are unclear. We tested the hypothesis that intrauterine fetal growth restriction caused by placental insufficiency results in low-birth-weight offspring with impaired endothelium-dependent vascular relaxation, enhanced vasoconstriction, and hype...
متن کاملRenal denervation abolishes hypertension in low-birth-weight offspring from pregnant rats with reduced uterine perfusion.
Low birth weight is a risk factor for the subsequent development of hypertension in humans. We previously reported that reduced uterine perfusion in the pregnant rat results in growth-restricted offspring predisposed to the development of hypertension. The purpose of this study was to determine whether the sympathetic nervous system plays a role in mediating hypertension in this model of low bi...
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High-salt (HS) diet is often associated with increased vascular resistance and arterial pressure; however, the effects of HS intake on the vascular control mechanisms of arterial pressure during pregnancy are unclear. We investigated whether a HS diet during pregnancy is associated with increases in vascular reactivity. Active stress was measured in aortic strips of virgin and normal pregnant S...
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Davis, Justin R., Jena B. Giardina, Gachavis M. Green, Barbara T. Alexander, Joey P. Granger, and Raouf A. Khalil. Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-induced hypertension in pregnant rats. Am J Physiol Regulatory Integrative Comp Physiol 282: R390–R399, 2002; 10.1152/ajpregu.00270.2001.—Placental ischemia during pregnancy is thought to release cytokines such as t...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2003
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.0000084990.88147.0c